There are multiple bus lines that lead to Madame Tussauds New York in Times Square.
Local Bus: M6, M7, M10, M16, M20, M27 & M104 to Times Square
Express Bus:
From Staten Island: X1, X6, X7, X9, X17J, X22, X30, X31
From Queens: X51, QM1, QM2, QM2A, QM3, QM4, QM10, QM12, QM15, QM16, QM17, QM18, QM22, QM24
From the Bronx: BxM2
Visit the Metropolitan Transit Authority at www.mta.info if you need more assistance.